| http://purl.uniprot.org/citations/30413707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30413707 | http://www.w3.org/2000/01/rdf-schema#comment | "Excess caloric intake results in increased fat accumulation and an increase in energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here we identify the neuropeptide FF receptor-2 (NPFFR2) as a critical regulator of diet-induced thermogenesis and bone homoeostasis. Npffr2-/- mice exhibit a stronger bone phenotype and when fed a HFD display exacerbated obesity associated with a failure in activating brown adipose tissue (BAT) thermogenic response to energy excess, whereas the activation of cold-induced BAT thermogenesis is unaffected. NPFFR2 signalling is required to maintain basal arcuate nucleus NPY mRNA expression. Lack of NPFFR2 signalling leads to a decrease in BAT thermogenesis under HFD conditions with significantly lower UCP-1 and PGC-1α levels in the BAT. Together, these data demonstrate that NPFFR2 signalling promotes diet-induced thermogenesis via a novel hypothalamic NPY-dependent circuitry thereby coupling energy homoeostasis with energy partitioning to adipose and bone tissue."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06462-0"xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Herzog H."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Lee N.J."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Low J.K."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Lee I.J."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Karl T."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Baldock P.A."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Enriquez R.F."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Ip C.K."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/author | "Reed F."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/pages | "4722"xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/title | "Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling."xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30413707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30413707 |
| http://purl.uniprot.org/citations/30413707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30413707 |
| http://purl.uniprot.org/uniprot/#_P57774-mappedCitation-30413707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30413707 |
| http://purl.uniprot.org/uniprot/#_Q924H0-mappedCitation-30413707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30413707 |
| http://purl.uniprot.org/uniprot/#_Q924N0-mappedCitation-30413707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30413707 |
| http://purl.uniprot.org/uniprot/Q924H0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30413707 |