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| http://purl.uniprot.org/citations/30419515 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional coactivators represent critical components of the transcriptional pre-initiation complex and are required for efficient gene activation. Members of the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) family differentially regulate hepatitis b virus (HBV) biosynthesis. Whereas PGC1α has been shown to be a potent activator of HBV biosynthesis, PGC1β only very poorly activates HBV RNA and DNA synthesis in human hepatoma (HepG2) and embryonic kidney (HEK293T) cells. Furthermore, PGC1β inhibits PGC1α-mediated HBV biosynthesis. These observations suggest that a potential competition between human hepatoma (HepG2) and embryonic kidney (HEK293T) cells PGC1α and PGC1β for common transcription factor target(s) may regulate HBV transcription and replication in a context and signal transduction pathway dependent manner."xsd:string |
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| http://purl.uniprot.org/citations/30419515 | http://purl.uniprot.org/core/author | "McLachlan A."xsd:string |
| http://purl.uniprot.org/citations/30419515 | http://purl.uniprot.org/core/author | "Iram S."xsd:string |
| http://purl.uniprot.org/citations/30419515 | http://purl.uniprot.org/core/author | "Oropeza C.E."xsd:string |
| http://purl.uniprot.org/citations/30419515 | http://purl.uniprot.org/core/author | "Shalaby R.E."xsd:string |
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| http://purl.uniprot.org/citations/30419515 | http://purl.uniprot.org/core/title | "Peroxisome proliferator-activated receptor gamma coactivator family members competitively regulate hepatitis b virus biosynthesis."xsd:string |
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