| http://purl.uniprot.org/citations/30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30422386 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes. However, other mechanisms of p130Cas signaling leading to malignant progression are poorly understood. Here, we show a novel interaction of p130Cas with Ser/Thr kinase PKN3, which is implicated in prostate and breast cancer growth downstream of phosphoinositide 3-kinase. This direct interaction is mediated by the p130Cas SH3 domain and the centrally located PKN3 polyproline sequence. PKN3 is the first identified Ser/Thr kinase to bind and phosphorylate p130Cas and to colocalize with p130Cas in cell structures that have a pro-invasive function. Moreover, the PKN3-p130Cas interaction is important for mouse embryonic fibroblast growth and invasiveness independent of Src transformation, indicating a mechanism distinct from that previously characterized for p130Cas. Together, our results suggest that the PKN3-p130Cas complex represents an attractive therapeutic target in late-stage malignancies."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.org/dc/terms/identifier | "doi:10.1002/1878-0261.12401"xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/author | "Rosel D."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/author | "Brabek J."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/author | "Gemperle J."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/author | "Dibus M."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/author | "Koudelkova L."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/pages | "264-289"xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/title | "The interaction of p130Cas with PKN3 promotes malignant growth."xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/30422386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30422386 |
| http://purl.uniprot.org/citations/30422386 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30422386 |
| http://purl.uniprot.org/uniprot/#_P56945-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
| http://purl.uniprot.org/uniprot/#_B2RBL9-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
| http://purl.uniprot.org/uniprot/#_A2BE96-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
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| http://purl.uniprot.org/uniprot/#_B3KWS6-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
| http://purl.uniprot.org/uniprot/#_Q3TXP6-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
| http://purl.uniprot.org/uniprot/#_Q05BU1-mappedCitation-30422386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30422386 |
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