| http://purl.uniprot.org/citations/30429161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30429161 | http://www.w3.org/2000/01/rdf-schema#comment | "Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The Platelet factor 4-Cre recombinase (Pf4-Cre) transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets and leukocytes work closely together in a wide range of disease settings, yet the specific contribution of platelets to these processes remains unclear. This is partially a result of the Pf4-Cre transgene being expressed in a variety of leukocyte populations. To overcome this issue, we developed a Gp1ba-Cre transgenic mouse strain in which Cre expression is driven by the endogenous Gp1ba locus. By crossing Gp1ba-Cre and Pf4-Cre mice to the mT/mG dual-fluorescence reporter mouse and performing a head-to-head comparison, we demonstrate more stringent megakaryocyte lineage-specific expression of the Gp1ba-Cre transgene. Broader tissue expression was observed with the Pf4-Cre transgene, leading to recombination in many hematopoietic lineages, including monocytes, macrophages, granulocytes, and dendritic and B and T cells. Direct comparison of phenotypes of Csk, Shp1, or CD148 conditional KO mice generated using either the Gp1ba-Cre or Pf4-Cre strains revealed similar platelet phenotypes. However, additional inflammatory and immunological anomalies were observed in Pf4-Cre-generated KO mice as a result of nonspecific deletion in other hematopoietic lineages. By excluding leukocyte contributions to phenotypes, the Gp1ba-Cre mouse will advance our understanding of the role of platelets in inflammation and other pathophysiological processes in which platelet-leukocyte interactions are involved."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2018-09-877787"xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Mori J."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Tarakhovsky A."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Nagy Z."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Senis Y.A."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Heising S."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Mazharian A."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Gareus R."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Desanti G.E."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Vogtle T."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Geer M.J."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/author | "Di Nunzio G."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/pages | "331-343"xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/title | "The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions."xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/30429161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30429161 |
| http://purl.uniprot.org/citations/30429161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30429161 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STA1-mappedCitation-30429161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30429161 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQQ5-mappedCitation-30429161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30429161 |