| http://purl.uniprot.org/citations/30429362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30429362 | http://www.w3.org/2000/01/rdf-schema#comment | "Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond. ARH1-deficient mice developed cardiomyopathy with myocardial fibrosis, decreased myocardial function under dobutamine stress, and increased susceptibility to ischemia/reperfusion injury. The membrane repair protein TRIM72 was identified as a substrate for ART1 and ARH1; ADP-ribosylated TRIM72 levels were greater in ARH1-deficient mice following ischemia/reperfusion injury. To understand better the role of TRIM72 and ADP-ribosylation, we used C2C12 myocytes. ARH1 knockdown in C2C12 myocytes increased ADP-ribosylation of TRIM72 and delayed wound healing in a scratch assay. Mutant TRIM72 (R207K, R260K) that is not ADP-ribosylated interfered with assembly of TRIM72 repair complexes at a site of laser-induced injury. The regulatory enzymes ART1 and ARH1 and their substrate TRIM72 were found in multiple complexes, which were coimmunoprecipitated from mouse heart lysates. In addition, the mono-ADP-ribosylation inhibitors vitamin K1 and novobiocin inhibited oligomerization of TRIM72, the mechanism by which TRIM72 is recruited to the site of injury. We propose that a mono-ADP-ribosylation cycle involving recruitment of TRIM72 and other regulatory factors to sites of membrane damage is critical for membrane repair and wound healing following myocardial injury."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.97898"xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Hoffmann V."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Moss J."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Murphy E."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Kato J."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Ishiwata-Endo H."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Stevens L.A."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "San H."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Tonouchi A."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Yu Z.X."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Aponte A.M."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Springer D.A."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/author | "Chung Y.W."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/pages | "97898"xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/title | "Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair."xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/30429362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30429362 |
| http://purl.uniprot.org/citations/30429362 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30429362 |