| http://purl.uniprot.org/citations/30442645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30442645 | http://www.w3.org/2000/01/rdf-schema#comment | "An inducible program of inflammatory gene expression is a hallmark of antimicrobial defenses. Recently, cellular nucleic acid-binding protein (CNBP) was identified as a regulator of nuclear factor-kappaB (NF-κB)-dependent proinflammatory cytokine gene expression. Here, we generated mice lacking CNBP and found that CNBP regulates a very restricted gene signature that includes IL-12β. CNBP resides in the cytosol of macrophages and translocates to the nucleus in response to diverse microbial pathogens and pathogen-derived products. Cnbp-deficient macrophages induced canonical NF-κB/Rel signaling normally but were impaired in their ability to control the activation of c-Rel, a key driver of IL-12β gene transcription. The nuclear translocation and DNA-binding activity of c-Rel required CNBP. Lastly, Cnbp-deficient mice were more susceptible to acute toxoplasmosis associated with reduced production of IL-12β, as well as a reduced T helper type 1 (Th1) cell IFN-γ response essential to controlling parasite replication. Collectively, these findings identify CNBP as important regulator of c-Rel-dependent IL-12β gene transcription and Th1 immunity."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20181031"xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Sharma S."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Gazzinelli R.T."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Sassetti C.M."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Knipe D.M."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Olive A.J."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Huh J.R."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Hang S."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Elling R."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Bernier J."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/author | "Assis P.A."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/pages | "3136-3150"xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/title | "CNBP controls IL-12 gene transcription and Th1 immunity."xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/30442645 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30442645 |
| http://purl.uniprot.org/citations/30442645 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30442645 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVS6-mappedCitation-30442645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30442645 |
| http://purl.uniprot.org/uniprot/#_P53996-mappedCitation-30442645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30442645 |