| http://purl.uniprot.org/citations/30446388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30446388 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital microscopy to analyze neutrophil emigration in cytokine-stimulated mouse cremaster muscles. We identified differential and non-redundant roles for the chemokines CXCL1 and CXCL2, governed by their distinct cellular sources. CXCL1 was produced mainly by TNF-stimulated endothelial cells (ECs) and pericytes and supported luminal and sub-EC neutrophil crawling. Conversely, neutrophils were the main producers of CXCL2, and this chemokine was critical for correct breaching of endothelial junctions. This pro-migratory activity of CXCL2 depended on the atypical chemokine receptor 1 (ACKR1), which is enriched within endothelial junctions. Transmigrating neutrophils promoted a self-guided migration response through EC junctions, creating a junctional chemokine "depot" in the form of ACKR1-presented CXCL2 that enabled efficient unidirectional luminal-to-abluminal migration. Thus, CXCL1 and CXCL2 act in a sequential manner to guide neutrophils through venular walls as governed by their distinct cellular sources."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.09.018"xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Thelen M."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Perez L."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Alon R."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Rot A."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Graham G."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Girbl T."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Sancho D."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Nourshargh S."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Voisin M.B."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Del Fresno C."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Thiriot A."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Hub E."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Rolas L."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Barkaway A."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Lenn T."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/author | "Lynam E."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/pages | "1062-1076.e6"xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/title | "Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis."xsd:string |
| http://purl.uniprot.org/citations/30446388 | http://purl.uniprot.org/core/volume | "49"xsd:string |