| http://purl.uniprot.org/citations/30457553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30457553 | http://www.w3.org/2000/01/rdf-schema#comment | "A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal development, a substantial proportion of Lasso is released into the intercellular space by regulated proteolysis, potentially precluding its function in synaptogenesis. We found that released Lasso binds to cell-surface latrophilin-1 on axonal growth cones. Using microfluidic devices to create stable gradients of soluble Lasso, we show that it induces axonal attraction, without increasing neurite outgrowth. Using latrophilin-1 knockout in mice, we demonstrate that latrophilin-1 is required for this effect. After binding latrophilin-1, Lasso causes downstream signaling, which leads to an increase in cytosolic calcium and enhanced exocytosis, processes that are known to mediate growth cone steering. These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.37935"xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Tonevitsky A.G."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Kozlov S.V."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Ushkaryov Y.A."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Lelianova V.G."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Silva J.P."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Suckling J."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Djamgoz M.B."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Cassidy J."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Yankova N."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Blackburn J.K."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/author | "Vysokov N.V."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/pages | "e37935"xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/title | "Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones."xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/30457553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30457553 |
| http://purl.uniprot.org/citations/30457553 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30457553 |
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| http://purl.uniprot.org/uniprot/#_B4DDN3-mappedCitation-30457553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30457553 |
| http://purl.uniprot.org/uniprot/#_B4DY80-mappedCitation-30457553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30457553 |