| http://purl.uniprot.org/citations/30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30463004 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent observations clearly highlight the critical role of type 2 innate lymphoid cells in maintaining the homeostasis of adipose tissues in humans and mice. This cell population promotes beiging and limits adiposity directly and indirectly by sustaining a Th2-prone environment enriched in eosinophils and alternatively activated macrophages. Accordingly, the number and function of type 2 innate lymphoid cells (ILC2s) are strongly impaired in obese individuals. In this work, we identify the PD-1-PD-L1 pathway as a factor leading to ILC2 destabilization upon high-fat feeding resulting in impaired tissue metabolism. Tumor necrosis factor (TNF) appears to play a central role, triggering interleukin-33 (IL-33)-dependent PD-1 expression on ILC2s and recruiting and activating PD-L1hi M1 macrophages. PD-1 blockade partially restores the type 2 innate axis, raising the possibility of restoring tissue homeostasis."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.10.091"xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Ryffel B."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Le Bert M."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Boon L."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Oldenhove G."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Acolty V."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Bonetti L."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Boucquey E."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Englebert K."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/author | "Taquin A."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/pages | "2053-2060.e4"xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/title | "PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity."xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/30463004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30463004 |
| http://purl.uniprot.org/citations/30463004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30463004 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30463004 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30463004 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30463004 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30463004 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-30463004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30463004 |