| http://purl.uniprot.org/citations/30464343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30464343 | http://www.w3.org/2000/01/rdf-schema#comment | "Development and routine tissue homeostasis require a high turnover of apoptotic cells. These cells are removed by professional and non-professional phagocytes via efferocytosis1. How a phagocyte maintains its homeostasis while coordinating corpse uptake, processing ingested materials and secreting anti-inflammatory mediators is incompletely understood1,2. Here, using RNA sequencing to characterize the transcriptional program of phagocytes actively engulfing apoptotic cells, we identify a genetic signature involving 33 members of the solute carrier (SLC) family of membrane transport proteins, in which expression is specifically modulated during efferocytosis, but not during antibody-mediated phagocytosis. We assessed the functional relevance of these SLCs in efferocytic phagocytes and observed a robust induction of an aerobic glycolysis program, initiated by SLC2A1-mediated glucose uptake, with concurrent suppression of the oxidative phosphorylation program. The different steps of phagocytosis2-that is, 'smell' ('find-me' signals or sensing factors released by apoptotic cells), 'taste' (phagocyte-apoptotic cell contact) and 'ingestion' (corpse internalization)-activated distinct and overlapping sets of genes, including several SLC genes, to promote glycolysis. SLC16A1 was upregulated after corpse uptake, increasing the release of lactate, a natural by-product of aerobic glycolysis3. Whereas glycolysis within phagocytes contributed to actin polymerization and the continued uptake of corpses, lactate released via SLC16A1 promoted the establishment of an anti-inflammatory tissue environment. Collectively, these data reveal a SLC program that is activated during efferocytosis, identify a previously unknown reliance on aerobic glycolysis during apoptotic cell uptake and show that glycolytic by-products of efferocytosis can influence surrounding cells."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0735-5"xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Makowski L."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Morioka S."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Rathmell J.C."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Leitinger N."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Medina C.B."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Perry J.S.A."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Kucenas S."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Raymond M.H."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Onengut-Gumuscu S."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/author | "Serbulea V."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/pages | "714-718"xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/title | "Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release."xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://purl.uniprot.org/core/volume | "563"xsd:string |
| http://purl.uniprot.org/citations/30464343 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30464343 |
| http://purl.uniprot.org/citations/30464343 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30464343 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-30464343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30464343 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRE8-mappedCitation-30464343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30464343 |