| http://purl.uniprot.org/citations/30466171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30466171 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-inducible gene I (RIG-I) is a critical RNA virus sensor that initiates antiviral immune response through K63-linked ubiquitination. In this study, we demonstrated USP14, a deubiquitinating enzyme, as a negative regulator in antiviral responses by directly deubiquitinating K63-linked RIG-I. USP14 knockdown significantly enhanced RIG-I-triggered type I IFN signaling and inhibited vesicular stomatitis virus (VSV) replication both in mouse peritoneal macrophages and THP1 cells. USP14 overexpression in HeLa cells attenuated RIG-I-triggered IFN-β expression and promoted VSV replication. Besides, USP14-specific inhibitor, IU1, increased RIG-I-mediated type I IFN production and antiviral responses in vitro and in vivo. In addition, USP14 could interact with RIG-I and remove RIG-I K63-linked polyubiquitination chains. This article is the first to report that USP14 acts as a negative regulator in antiviral response through deubiquitinating K63-linked RIG-I. These findings provide insights into a potential new therapy targeting USP14 for RNA virus-related diseases."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201847603"xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Ling J."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/author | "Xie B."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/pages | "42-53"xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/title | "USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses."xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/30466171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30466171 |
| http://purl.uniprot.org/citations/30466171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30466171 |
| http://purl.uniprot.org/uniprot/#_B2RD79-mappedCitation-30466171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30466171 |
| http://purl.uniprot.org/uniprot/#_B3KTG4-mappedCitation-30466171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30466171 |
| http://purl.uniprot.org/uniprot/#_P54578-mappedCitation-30466171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30466171 |
| http://purl.uniprot.org/uniprot/P54578 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30466171 |
| http://purl.uniprot.org/uniprot/B3KTG4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30466171 |