| http://purl.uniprot.org/citations/30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30471852 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipopolysaccharide (LPS) induces macrophage/monocyte activation and pro-inflammatory cytokines production by activating Toll-like receptor 4 (TLR-4) signaling. Rab GTPase 21 (Rab21) is a member of the Rab GTPase subfamily. In the present study, we show that LPS induced TLR4 and Rab21 association and endosomal translocation in murine bone marrow-derived macrophages (BMDMs) and primary human peripheral blood mononuclear cells (PBMCs). In BMDMs, shRNA-mediated stable knockdown of Rab21 inhibited LPS-induced expression and production of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α). Conversely, forced overexpression of Rab21 by an adenovirus construct potentiated LPS-induced IL-1β, IL-6 and TNF-α production in BMDMs. Further studies show that LPS-induced TLR4 endosomal traffic and downstream c-Jun and NFκB (nuclear factor-kappa B) activation were significantly inhibited by Rab21 shRNA, but intensified with Rab21 overexpression in BMDMs. Finally, in the primary human PBMCs, siRNA-induced knockdown of Rab21 significantly inhibited LPS-induced IL-1β, IL-6 and TNF-α production. Taken together, we suggest that Rab21 regulates LPS-induced pro-inflammatory responses by promoting TLR4 endosomal traffic and downstream signaling activation."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.11.074"xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/author | "Li M.X."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/author | "Wu Y.H."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/author | "Zhu Y.T."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/author | "Pei H.H."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/pages | "169-176"xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/title | "Requirement of Rab21 in LPS-induced TLR4 signaling and pro-inflammatory responses in macrophages and monocytes."xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://purl.uniprot.org/core/volume | "508"xsd:string |
| http://purl.uniprot.org/citations/30471852 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30471852 |
| http://purl.uniprot.org/citations/30471852 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30471852 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_L0CL36-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_L0CMZ8-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_Q3U4D4-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_Q8K2T5-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_U5LHT3-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_V9PC02-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_V9PC04-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_V9PC06-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |
| http://purl.uniprot.org/uniprot/#_Q9QUK6-mappedCitation-30471852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30471852 |