| http://purl.uniprot.org/citations/30472188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30472188 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional regulators YAP and TAZ play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. It is yet unknown why the YAP/ TAZ proteins are frequently activated in human malignancies in which the Hippo pathway is still active. Here, by a gain-of-function cancer metastasis screen, we discovered OTUB2 as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates YAP/TAZ. We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ. We also identified a yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ required for their association with SUMOylated OTUB2. Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ. Our results establish OTUB2 as an essential modulator of YAP/TAZ and also reveal a novel mechanism via which YAP/TAZ activity is induced by oncogenic KRAS."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.10.030"xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Ding C."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Shao L."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Wang A."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Wei B."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Zheng M."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Ding W."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Jin K."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Feng X.H."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "van Dam H."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/author | "Fu P."xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/pages | "7-21.e7"xsd:string |
| http://purl.uniprot.org/citations/30472188 | http://purl.uniprot.org/core/title | "OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ."xsd:string |