| http://purl.uniprot.org/citations/30475225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30475225 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate the detailed metabolic profile of SLC16A11 risk haplotype carriers to identify potential physiological mechanisms explaining the increased type 2 diabetes risk. Design Cross-sectional study. Methods We evaluated carriers (n = 72) and non-carriers (n = 75) of the SLC16A11 risk haplotype, with or without type 2 diabetes. An independent sample of 1069 subjects was used to replicate biochemical findings. The evaluation included euglycemic-hyperinsulinemic clamp, frequently sampled intravenous glucose tolerance test (FSIVGTT), dual-energy X-ray absorptiometry (DXA), MRI and spectroscopy and subcutaneous abdominal adipose tissue biopsies. Results Fat-free mass (FFM)-adjusted M value was lower in carriers of the SLC16A11 risk haplotype after adjusting for age and type 2 diabetes status (β = -0.164, P = 0.04). Subjects with type 2 diabetes and the risk haplotype demonstrated an increase of 8.76 U/L in alanine aminotransferase (ALT) (P = 0.02) and of 7.34 U/L in gamma-glutamyltransferase (GGT) (P = 0.05) compared with non-carriers and after adjusting for gender, age and ancestry. Among women with the risk haplotype and normal BMI, the adipocyte size was higher (P < 0.001). Conclusions Individuals carrying the SLC16A11 risk haplotype exhibited decreased insulin action. Higher serum ALT and GGT levels were found in carriers with type 2 diabetes, and larger adipocytes in subcutaneous fat in the size distribution in carrier women with normal weight."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.org/dc/terms/identifier | "doi:10.1530/eje-18-0677"xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Clark P."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Florez J.C."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Jacobs S.B.R."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Walford G.A."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Ordonez-Sanchez M.L."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Aguilar-Salinas C.A."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Moreno-Macias H."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Zambrano E."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Cruz-Bautista I."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Furuzawa-Carballeda J."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Almeda-Valdes P."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Huerta-Chagoya A."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Bello-Chavolla O.Y."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Arellano Campos O."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Azpiroz J."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Bautista C.J."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Del Rocio Sevilla-Gonzalez M."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Gomez Velasco D.V."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Guillen Pineda L.E."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Herrera-Hernandez M.F."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Martagon Rosado A.J."xsd:string |
| http://purl.uniprot.org/citations/30475225 | http://purl.uniprot.org/core/author | "Munoz Hernandez L."xsd:string |