| http://purl.uniprot.org/citations/30479651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30479651 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundPrevious study revealed that rs2232618 polymorphism (Phe436Leu) within LBP gene is a functional variant and associated with susceptibility of sepsis in traumatic patients. Our aim was to confirm the reported association by enlarging the population sample size and perform a meta-analysis to find additional evidence.MethodsTraumatic patients from Southwest (n = 1296) and Southeast (n = 445) of China were enrolled in our study. After genotyping, the relationship between rs2232618 and the risk of sepsis was analyzed. Furthermore, we proceeded with a comprehensive literature search and meta-analysis to determine whether the rs2232618 polymorphism conferred susceptibility to sepsis.ResultsSignificance correlation was observed between rs2232618 and risk of sepsis in Southwest patients (P = 0.002 for the dominant model, P = 0.006 for the recessive model). The association was confirmed in Southeast cohort (P = 0.005 for the dominant model) and overall combined cohorts (P = 4.5 × 10-4, P = 0.041 for the dominant and recessive model). Multiple logistical regression analyses suggested that rs2232618 polymorphism was related to higher risk of sepsis (OR = 1.77, 95% CI = 1.26-2.48, P = 0.001 in Southwest patients; OR = 2.11, 95% CI = 1.24-3.58, P = 0.006 in Southeast cohort; OR = 1.54, 95% CI = 1.34-2.08, P = 0.006 in overall cohort). Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, P < 0.001 for the dominant model; OR = 6.08, P = 0.003 for the recessive model; OR = 2.72, P < 0.001 for the allelic model).ConclusionsThe results from our replication study and meta-analysis provided firm evidence that rs2232618T allele significantly increased the risk of sepsis."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13017-018-0214-1"xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Jiang J.X."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Lu H.X."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Sun J.H."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Zhang A.Q."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/author | "Wen D.L."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/name | "World J Emerg Surg"xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/pages | "52"xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/title | "LBP rs2232618 polymorphism contributes to risk of sepsis after trauma."xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/30479651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30479651 |
| http://purl.uniprot.org/citations/30479651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30479651 |
| http://purl.uniprot.org/uniprot/#_P18428-mappedCitation-30479651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30479651 |
| http://purl.uniprot.org/uniprot/#_Q8TCF0-mappedCitation-30479651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30479651 |
| http://purl.uniprot.org/uniprot/P18428 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30479651 |
| http://purl.uniprot.org/uniprot/Q8TCF0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30479651 |