http://purl.uniprot.org/citations/30481381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/30481381 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and objectivesThe aim of the study was to understand the importance of mismatch repair genes MLH1 and MSH2 in chemotolerance and prognosis of breast carcinoma (BC).MethodsFirst, the alterations (deletion/methylation/expression) of MLH1 and MSH2 were analyzed in 45 neoadjuvant chemotherapy (NACT)-treated and 133 pretherapeutic BC samples. The chemotolerant BC cells were characterized by treating two BC cell lines MCF-7 and MDA MB 231 with two anthracycline antitumor antibiotics, doxorubicin and nogalamycin.ResultsThe deletion frequencies were 32% to 38% in MLH1/MSH2 genes and promoter methylation frequencies were 49% to 62% in MLH1 and 41% to 51% in MSH2 in both NACT-treated and pretherapeutic samples. The overall alteration of MLH1 and MSH2 was 58% to 71% in the samples. Reduced messenger RNA (mRNA) and protein expression were found in both the genes and it showed concordance with the molecular alterations. NACT-treated patients showed better prognosis. The chemotherapeutic drug induced increased mRNA/protein expression of the genes in BC cell lines was due to their promoter hypomethylation, as analyzed by quantitative methylation assay. This phenomenon was also evident in NACT-treated BC samples.ConclusionMLH1/MSH2 genes play a critical role in the development of BC. Hypomethylation of MLH1/MSH2 genes might be important in chemotolerance of the disease."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.org/dc/terms/identifier | "doi:10.1002/jso.25304"xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Islam S."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Roy A."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Alam N."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Roychoudhury S."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Panda C.K."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/author | "Dasgupta H."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/name | "J Surg Oncol"xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/pages | "88-100"xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/title | "Hypomethylation of mismatch repair genes MLH1 and MSH2 is associated with chemotolerance of breast carcinoma: Clinical significance."xsd:string |
http://purl.uniprot.org/citations/30481381 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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