| http://purl.uniprot.org/citations/30483269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30483269 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T cells are key players during infection with the malaria parasite Plasmodium berghei ANKA (PbA). While they cannot provide protection against blood-stage parasites, they can cause immunopathology, thus leading to the severe manifestation of cerebral malaria. Hence, the tight control of CD8+ T cell function is key in order to prevent fatal outcomes. One major mechanism to control CD8+ T cell activation, proliferation and effector function is the integration of co-inhibitory and co-stimulatory signals. In this study, we show that one such pathway, the HVEM-CD160 axis, significantly impacts CD8+ T cell regulation and thereby the incidence of cerebral malaria. Here, we show that the co-stimulatory molecule HVEM is indeed required to maintain CD8+ T effector populations during infection. Additionally, by generating a CD160-/- mouse line, we observe that the HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8+ T effector cells, thereby restricting immunopathology. Importantly, CD160 is also induced on cytotoxic CD8+ T cells during acute Plasmodium falciparum malaria in humans. In conclusion, CD160 is specifically expressed on highly activated CD8+ T effector cells that are harmful during the blood-stage of malaria."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.02611"xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Jacobs T."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Schramm C."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Schulze Zur Wiesch J."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Bosurgi L."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Muscate F."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/author | "Stetter N."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/pages | "2611"xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/title | "HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage."xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30483269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30483269 |
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