| http://purl.uniprot.org/citations/30484334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30484334 | http://www.w3.org/2000/01/rdf-schema#comment | "Aims: Heme oxygenase-1 (HO-1) is an enzyme involved in cellular responses to oxidative stress and has also been shown to regulate processes related to cancer progression. In this regard, HO-1 has been shown to display a dual effect with either antitumor or protumor activity, which is also true for breast cancer (BC). In this work, we address this discrepancy regarding the role of HO-1 in BC. Results: HO-1 was detected in human BC tissues, and its protein levels correlated with reduced tumor size and longer overall survival time of patients, thus suggesting the clinical importance of HO-1 in this type of cancer. Contrariwise, nuclear localization of HO-1 correlated with higher tumor grade suggesting that the effect of HO-1 is dependent on its cellular localization. In vivo experiments showed that both pharmacological activation and genetic overexpression of HO-1 reduce the tumor burden in two different animal models of BC. Furthermore, the pharmacological and genetic activation of HO-1 in several BC cell lines reduce the cellular viability by inducing apoptosis and cell cycle arrest and decrease the cellular migration and invasion rates by modulating pathways involved in the epithelial-mesenchymal transition. Furthermore, HO-1 activation impaired in vivo the metastatic dissemination. Innovation and Conclusion: By using various BC cell lines and animal models as well as human tumor samples, we demonstrated that total HO-1 displays antitumor activities in BC. Furthermore, our study suggests that HO-1 subcellular localization may explain the differential effects observed for the protein in different tumor types."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.org/dc/terms/identifier | "doi:10.1089/ars.2018.7554"xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Mascaro M."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Abba M.C."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Curino A.C."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Nunez M."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Arevalo J."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Guevara J.A."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Facchinetti M.M."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Colo G.P."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Fermento M.E."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Gandini N.A."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Ferronato M.J."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Alonso E.N."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/author | "Pichel P."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/name | "Antioxid Redox Signal"xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/pages | "2030-2049"xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/title | "Heme Oxygenase-1 Has an Antitumor Role in Breast Cancer."xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/30484334 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30484334 |
| http://purl.uniprot.org/citations/30484334 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30484334 |
| http://purl.uniprot.org/uniprot/#_F2YMD9-mappedCitation-30484334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30484334 |
| http://purl.uniprot.org/uniprot/#_D2K7W4-mappedCitation-30484334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30484334 |