| http://purl.uniprot.org/citations/30485803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30485803 | http://www.w3.org/2000/01/rdf-schema#comment | "Plant "nucleotide-binding leucine-rich repeat" receptor proteins (NLRs) detect alterations in host targets of pathogen effectors and trigger immune responses. The Arabidopsis thaliana mutant pen1 syp122 displays autoimmunity, and a mutant screen identified the deubiquitinase "associated molecule with the SH3 domain of STAM3" (AMSH3) to be required for this phenotype. AMSH3 has previously been implicated in ESCRT-mediated vacuolar targeting. Pathology experiments show that AMSH3 activity is required for immunity mediated by the CC-NLRs, RPS2 and RPM1. Co-expressing the autoactive RPM1D505V and the catalytically inactive ESCRT-III protein SKD1E232Q in Nicotiana benthamiana supports the requirement of ESCRT-associated functions for this CC-NLR-activated immunity. Meanwhile, loss of ESCRT function in A. thaliana is lethal, and we find that AMSH3 knockout-triggered seedling lethality is "enhanced disease susceptibility 1" (EDS1) dependent. Future studies may reveal whether AMSH3 is monitored by a TIR-NLR immunity receptor."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.11.011"xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Thordal-Christensen H."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Lenk A."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Pedersen C."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Isono E."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Kalinowska K."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Schultz-Larsen T."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/author | "Vestergaard L.K."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/pages | "2329-2338.e5"xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/title | "The AMSH3 ESCRT-III-Associated Deubiquitinase Is Essential for Plant Immunity."xsd:string |
| http://purl.uniprot.org/citations/30485803 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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