| http://purl.uniprot.org/citations/30487290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30487290 | http://www.w3.org/2000/01/rdf-schema#comment | "Kras-driven non-small-cell lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Many NSCLCs exhibit high levels of Ezh2, the enzymatic subunit of polycomb repressive complex 2 (PRC2). We tested Ezh2 inhibitors as single agents or before chemotherapy in mice with orthotopic Kras-driven NSCLC grafts, which homogeneously express Ezh2. These tumors display sensitivity to EZH2 inhibition by GSK126 but also amplify an inflammatory program involving signaling through NF-κB and genes residing in PRC2-regulated chromatin. During this process, tumor cells overcome GSK126 antiproliferative effects. We identified oncogenes that may mediate progression through an in vivo RNAi screen aimed at targets of PRC2/NF-κB. An in vitro compound screening linked GSK126-driven inflammation and therapeutic vulnerability in human cells to regulation of RNA synthesis and proteostasis. Interestingly, GSK126-treated NSCLCs in vivo also showed an enhanced response to a combination of nimesulide and bortezomib. Thus, Ezh2 inhibition may restrict cell proliferation and promote defined adaptive responses. Targeting these responses potentially improves outcomes in Kras-driven NSCLCs."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20180801"xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Morris B."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Schmitt M.J."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Beijersbergen R.L."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Gargiulo G."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Cesaroni M."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "van Lohuizen M."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Serresi M."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Hulsman D."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Company C."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Proost N."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Lieftink C."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/author | "Siteur B."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/pages | "3115-3135"xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/title | "Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities."xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/30487290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30487290 |
| http://purl.uniprot.org/citations/30487290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30487290 |
| http://purl.uniprot.org/uniprot/#_F2YMM1-mappedCitation-30487290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30487290 |
| http://purl.uniprot.org/uniprot/#_A0A090N8E9-mappedCitation-30487290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30487290 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-30487290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30487290 |