http://purl.uniprot.org/citations/30487699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/30487699 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo uncover the roles of tumor-promoting gene ZEB1 in aerobic glycolysis regulation and shed light on the underlying molecular mechanism.MethodsEndogenous zinc finger E-box binding homeobox-1 (ZEB1) was silenced using a lentivirus-mediated method, and the impact of ZEB1 and methyl-CpG binding domain protein 1 (MBD1) on aerobic glycolysis was measured using seahorse cellular flux analyzers, reactive oxygen species quantification, and mitochondrial membrane potential measurement. The interaction between ZEB1 and MBD1 was assessed by co-immunoprecipitation and immunofluorescence assays. The impact of ZEB1 and MBD1 interaction on sirtuin 3 (SIRT3) expression was confirmed by quantitative polymerase chain reaction, western blotting, and dual-luciferase and chromatin-immunoprecipitation assays.ResultsZEB1 was a positive regulator of aerobic glycolysis in pancreatic cancer. ZEB1 transcriptionally silenced expression of SIRT3, a mitochondrial-localized tumor suppressor, through interaction with MBD1.ConclusionZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.org/dc/terms/identifier | "doi:10.3748/wjg.v24.i43.4893"xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Yu X.J."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Liu W.S."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Xu W.Y."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Ni Q.X."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/author | "Hu Q.S."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/name | "World J Gastroenterol"xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/pages | "4893-4905"xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/title | "Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer."xsd:string |
http://purl.uniprot.org/citations/30487699 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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