| http://purl.uniprot.org/citations/30498219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30498219 | http://www.w3.org/2000/01/rdf-schema#comment | "Inputs from olfactory sensory neuron (OSN) axons expressing the same type of odorant receptor (OR) converge in the glomerulus of the main olfactory bulb. A key marker of mature OSNs is olfactory marker protein (OMP), whose deletion has been associated with deficits in OSN signal transduction and odor discrimination. Here, we investigate glomerular odor responses and anatomical architecture in mice in which one or both alleles of OMP are replaced by the fluorescent synaptic activity reporter, synaptopHluorin. Functionally heterogeneous glomeruli, that is, ones with microdomains with distinct odor responses, are rare in OMP+/- mice, but occur frequently in OMP-/- mice. Genetic targeting of single ORs reveals that these microdomains arise from co-innervation of individual glomeruli by OSNs expressing different ORs. This glomerular mistargeting is locally restricted to a few glomerular diameters. Our studies document functional heterogeneity in sensory input within individual glomeruli and uncover its anatomical correlate, revealing an unexpected role for OMP in the formation and refinement of the glomerular map."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-07544-9"xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Agarwal P."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Soucy E.R."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Murthy V.N."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Provost A.C."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Albeanu D.F."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/author | "Zak J.D."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/pages | "5073"xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/title | "Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map."xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30498219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30498219 |
| http://purl.uniprot.org/citations/30498219 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30498219 |
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| http://purl.uniprot.org/uniprot/#_Q64288-mappedCitation-30498219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30498219 |
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