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http://purl.uniprot.org/citations/30503877http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30503877http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The purpose of this study was to examine the association of circulating concentrations of high-sensitivity cardiac troponin I (hs-cTn) in the various trimesters of pregnancy in patients with and without hypertension.

Methods

This was a prospective cross-sectional study of pregnant and postnatal women aged between 18-35 years with no coexisting diseases. Serum samples were analysed for hs-TnI.

Results

A total of 880 women (mean age = 29.1 years [standard deviation = 5.1 years]) were recruited with 129 (14%), 207 (24%), and 416 (47%) patients in the first, second, and third trimesters, respectively. Ninety (10%) participants were recruited in the postnatal period. During pregnancy 28 (3%) patients were classified as having pregnancy-induced hypertension and 10 (1%) as preeclampsia. High-sensitivity cardiac troponin I was measurable in 546 (62%) participants with a median of 1 ng/L (range 0 to 783 ng/L). Troponin concentrations were above the 99th percentile in 19 (2%) individuals. Patients with pregnancy-induced hypertension and preeclampsia had higher concentrations of hs-TnI (median 11 ng/L [interquartile range (IQR) 6 to 22 ng/L] vs 12ng/L [IQR 3 to 98 ng/L] vs 1 ng/L [IQR 0 to 1 ng/L]). In logistic regression modeling hs-cTnI concentration remained an independent predictor of pregnancy-induced hypertension or preeclampsia in both unadjusted and adjusted models (odds ratio 9.3 [95% confidence interval 5.8 to 16.3] and 11.5 [95% confidence interval 6.3 to 24.1], respectively, per doubling of hs-TnI concentrations).

Conclusions

Cardiac troponin measured using a high-sensitivity assay is quantifiable in the majority of young pregnant women with 2% of individuals having concentration above the 99th percentile sex-specific threshold. Patients with pregnancy-induced hypertension or preeclampsia had higher cardiac troponin concentrations. Cardiac troponin was a strong independent predictor of pregnancy-induced hypertension or preeclampsia in pregnant and postnatal women."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.org/dc/terms/identifier"doi:10.1016/j.amjmed.2018.11.017"xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Shah A."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Jaffe A.S."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Lim Y.C."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Quek Y.S."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Suresh K."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Ravichandran J."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Mills N.L."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Beshiri A."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Noor E.M."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Sickan J."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Vasile V."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Vigneswaran R."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/author"Woon S.Y."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/name"Am J Med"xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/pages"362-366"xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/title"High-Sensitivity Cardiac Troponin I Levels in Normal and Hypertensive Pregnancy."xsd:string
http://purl.uniprot.org/citations/30503877http://purl.uniprot.org/core/volume"132"xsd:string
http://purl.uniprot.org/citations/30503877http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30503877
http://purl.uniprot.org/citations/30503877http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/30503877
http://purl.uniprot.org/uniprot/#_A0A1B1HY27-mappedCitation-30503877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30503877
http://purl.uniprot.org/uniprot/#_A9UD06-mappedCitation-30503877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30503877
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