| http://purl.uniprot.org/citations/30504064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30504064 | http://www.w3.org/2000/01/rdf-schema#comment | "KIAA1549-BRAF is the most frequently identified genetic mutation in sporadic pilocytic astrocytoma (PA), creating a fusion BRAF (f-BRAF) protein with increased BRAF activity. Fusion-BRAF-expressing neural stem cells (NSCs) exhibit increased cell growth and can generate glioma-like lesions following injection into the cerebella of naïve mice. Increased Iba1+ monocyte (microglia) infiltration is associated with murine f-BRAF-expressing NSC-induced glioma-like lesion formation, suggesting that f-BRAF-expressing NSCs attract microglia to establish a microenvironment supportive of tumorigenesis. Herein, we identify Ccl2 as the chemokine produced by f-BRAF-expressing NSCs, which is critical for creating a permissive stroma for gliomagenesis. In addition, f-BRAF regulation of Ccl2 production operates in an ERK- and NFκB-dependent manner in cerebellar NSCs. Finally, Ccr2-mediated microglia recruitment is required for glioma-like lesion formation in vivo, as tumor do not form in Ccr2-deficient mice following f-BRAF-expressing NSC injection. Collectively, these results demonstrate that f-BRAF expression creates a supportive tumor microenvironment through NFκB-mediated Ccl2 production and microglia recruitment."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neo.2018.11.007"xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Gutmann D.H."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Lober R.M."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Waker C.A."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/author | "Keoni C."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/name | "Neoplasia"xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/pages | "52-60"xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/title | "KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFkappaB-Mediated CCL2 Production."xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/30504064 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30504064 |
| http://purl.uniprot.org/citations/30504064 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30504064 |
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| http://purl.uniprot.org/uniprot/P15056 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30504064 |
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