| http://purl.uniprot.org/citations/30504124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30504124 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling controls neuronal migration in metazoans, in addition to many other aspects of neural development. We show that Caenorhabditis elegans VANG-1, a membrane protein that acts in the planar cell polarity (PCP) pathway, antagonizes Wnt signaling by facilitating endocytosis of the Frizzled receptors. Mutations of vang-1 suppress migration defects of multiple classes of neurons in the Frizzled mutants, and overexpression of vang-1 causes neuronal migration defects similar to those of the Frizzled mutants. Our genetic experiments suggest that VANG-1 facilitates Frizzled endocytosis through β-arrestin2. Co-immunoprecipitation experiments indicate that Frizzled proteins and VANG-1 form a complex, and this physical interaction requires the Frizzled cysteine-rich domain. Our work reveals a novel mechanism mediated by the PCP protein VANG-1 that downregulates Wnt signaling through Frizzled endocytosis."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.168666"xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "Liao C.P."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "He C.W."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "Chen C.K."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "Pan C.L."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/author | "Teuliere J."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/pages | "dev168666"xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/title | "The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis."xsd:string |
| http://purl.uniprot.org/citations/30504124 | http://purl.uniprot.org/core/volume | "145"xsd:string |
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