DESCRIBE <http://purl.uniprot.org/citations/30504385>

Subject	Predicate	Object
http://purl.uniprot.org/citations/30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30504385	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aim Most melanomas develop in hypoxic conditions. Since hypoxia via HIF-1 induces glycolysis, a process essential for malignant melanoma growth/survival, the goal of this study was to analyze the influence of hypoxia on the expression of HIF-1 target genes involved in glucose metabolism. Materials and methods The response of melanoma cell lines to hypoxic conditions was analyzed by RT-PCR and western blotting. A Kaplan-Meier survival analysis for patients with high and low expression level of PFKFB4 was performed. Further analysis of patients' data was performed using the R/Bioconductor environment. Results Induction of PFKFB4 gene expression can be considered a crucial mechanism behind glycolysis enhancement in hypoxic melanoma cells. Analysis of a publicly available database revealed that high PFKFB4 expression contributes to poor prognosis of melanoma patients. Conclusion Currently available anti-melanoma therapeutic strategies may significantly benefit from agents targeting PFKFB4 activity."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.org/dc/terms/identifier	"doi:10.21873/anticanres.13044"xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/author	"Laidler P."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/author	"Piwowar M."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/author	"Kocemba-Pilarczyk K.A."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/author	"Ostrowska B."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/author	"Trojan S.E."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/date	"2018"xsd:gYear
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/name	"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/pages	"6745-6752"xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/title	"Analysis of Malignant Melanoma Cell Lines Exposed to Hypoxia Reveals the Importance of PFKFB4 Overexpression for Disease Progression."xsd:string
http://purl.uniprot.org/citations/30504385	http://purl.uniprot.org/core/volume	"38"xsd:string
http://purl.uniprot.org/citations/30504385	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/30504385
http://purl.uniprot.org/citations/30504385	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/30504385
http://purl.uniprot.org/uniprot/#_B2R6L2-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/#_B7Z5L3-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/#_B7Z5C3-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/#_Q16877-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/#_Q66S35-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/#_Q5XLC3-mappedCitation-30504385	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/Q5XLC3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/Q16877	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/B7Z5L3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/30504385
http://purl.uniprot.org/uniprot/Q66S35	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/30504385