| http://purl.uniprot.org/citations/30508555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30508555 | http://www.w3.org/2000/01/rdf-schema#comment | "α-Naphthoflavone (αNF) is a prototype flavone, also known as a modulator of aryl hydrocarbon receptor (AhR). In the present study, we investigated the molecular mechanisms of αNF-induced cytotoxic effects in HT22 mouse hippocampal neuronal cells. αNF induced apoptotic cell death via activation of caspase-12 and -3 and increased expression of endoplasmic reticulum (ER) stress-associated proteins, including C/EBP homologous protein (CHOP). Inhibition of ER stress by treatment with the ER stress inhibitor, salubrinal, or by CHOP siRNA transfection reduced αNF-induced cell death. αNF activated mitogen-activated protein kinases (MAPKs), such as p38, JNK, and ERK, and inhibition of MAPKs reduced αNF-induced CHOP expression and cell death. αNF also induced accumulation of reactive oxygen species (ROS) and an antioxidant, N-acetylcysteine, reduced αNF-induced MAPK phosphorylation, CHOP expression, and cell death. Furthermore, αNF activated c-Src kinase, and inhibition of c-Src by a kinase inhibitor, SU6656, or siRNA transfection reduced αNF-induced ROS accumulation, MAPK activation, CHOP expression, and cell death. Inhibition of AhR by an AhR antagonist, CH223191, and siRNA transfection of AhR and AhR nuclear translocator reduced αNF-induced AhR-responsive luciferase activity, CHOP expression, and cell death. Finally, we found that inhibition of c-Src and MAPKs reduced αNF-induced transcriptional activity of AhR. Taken together, these findings suggest that αNF induces apoptosis through ER stress via c-Src-, ROS-, MAPKs-, and AhR-dependent pathways in HT22 cells."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuro.2018.11.011"xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Kim S.S."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Kang I."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Ha J."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Jeong Y.J."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Yoon K.S."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Pak Y.K."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Hwang C.Y."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Choe W."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Yeo E.J."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/author | "Yu A.R."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/name | "Neurotoxicology"xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/pages | "39-51"xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/title | "Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/30508555 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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