| http://purl.uniprot.org/citations/30508596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30508596 | http://www.w3.org/2000/01/rdf-schema#comment | "As an RNA binding protein, CUG-BP Elav-like family (CELF) has been shown to be critical for heart biological functions. However, no reports have revealed the function of CELF1 in hypertrophic cardiomyopathy (HCM). Hinted by RNA immunoprecipitation-sequencing (RIP-seq) data, the influence of the CELF protein on heme oxygenase-1 (HO-1) expression was tested by modulating CELF1 levels. Cardiac hypertrophy is related to oxidative stress-induced damage. Hence, the cardiovascular system may be protected against further injury by upregulating the expression of antioxidant enzymes, such as HO-1. During the past two decades, research has demonstrated the central role of HO-1 in the protection against diseases. Thus, understanding the molecular mechanisms underlying the modulation of HO-1 expression is profoundly important for developing new strategies to prevent cardiac hypertrophy. To elucidate the molecular mechanisms underlying HO-1 regulation by the CELF protein, we performed RNA immunoprecipitation (RIP), biotin pull-down analysis, luciferase reporter and mRNA stability assays. We found that the expression of HO-1 was downregulated by CELF1 through the conserved GU-rich elements (GREs) in HO-1 3'UTR transcripts. Correspondingly, CELF1 expression was regulated by controlling the release of carbon monoxide (CO) in H9C2 cells. The CELF1-HO-1-CO regulation axis constituted a novel positive feedback circuit. In addition, we detected the potential involvement of CELF1 and HO-1 in samples from HCM patients. We found that CELF1 and CELF2, but not HO-1, were highly expressed in HCM heart samples. Thus, a manipulation targeting CELF1 could be developed as a potential therapeutic option for cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2018.11.006"xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Wei B."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Ji G."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Dai J."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Cao D."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/author | "Nyirimigabo E."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Gene Regul Mech"xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/pages | "209-218"xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/title | "A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells."xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://purl.uniprot.org/core/volume | "1862"xsd:string |
| http://purl.uniprot.org/citations/30508596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30508596 |
| http://purl.uniprot.org/citations/30508596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30508596 |
| http://purl.uniprot.org/uniprot/Q792H5#attribution-0F09207C22290176277BE85A7523BC7B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30508596 |
| http://purl.uniprot.org/uniprot/Q792H5#attribution-2B18F9A96E708E4991B084B6737D2239 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30508596 |
| http://purl.uniprot.org/uniprot/Q4QQT3#attribution-0F09207C22290176277BE85A7523BC7B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30508596 |
| http://purl.uniprot.org/uniprot/Q4QQT3#attribution-2B18F9A96E708E4991B084B6737D2239 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30508596 |