| http://purl.uniprot.org/citations/30520817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30520817 | http://www.w3.org/2000/01/rdf-schema#comment | "The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. This study was undertaken to investigate whether the HTN3-MSANTD3 fusion is a recurrent genetic event in AciCC and whether it is a characteristic of one of its histological variants. Of the 273 AciCCs screened, 9 cases showed rearrangement of MSANTD3 by break-apart fluorescence in situ hybridization, 2 had 1 to 2 extra signals, and 1 had gain, giving a total of 4.4% with MSANTD3 aberrations. In 6 of 7 available cases with MSANTD3 rearrangement, the HTN3-MSANTD3 fusion transcript was demonstrated with real-time polymerase chain reaction. Histologically, all fusion-positive cases were predominantly composed of serous tumor cells growing in solid sheets, with serous tumor cells expressing DOG-1 and the intercalated duct-like cell component being CK7 positive and S-100 positive in 6/9 cases. All but one case arose in the parotid gland, and none of the patients experienced a recurrence during follow-up. In contrast, the case with MSANTD3 gain metastasized to the cervical lymph nodes and lungs. In conclusion, we find the HTN3-MSANTD3 gene fusion to be a recurrent event in AciCC with prominent serous differentiation and an indolent clinical course."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.org/dc/terms/identifier | "doi:10.1097/pas.0000000000001200"xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Kiss K."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "West R.B."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Varma S."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Pollack J.R."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Miettinen M."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Stelow E.B."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Bishop J.A."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Larsen S.R."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Homoe P."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Wessel I."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Seethala R.R."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Chiosea S.I."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Ulhoi B.P."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Rooper L."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Barasch N."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Agander T.K."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Andreasen S."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Erentaite D."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Melchior L.C."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/author | "Thompson L.D.R."xsd:string |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30520817 | http://purl.uniprot.org/core/name | "Am J Surg Pathol"xsd:string |