| http://purl.uniprot.org/citations/30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30523780 | http://www.w3.org/2000/01/rdf-schema#comment | "The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that initiate homologous recombination in eukaryotic cells. Sae2/CtIP is also important for survival of single-stranded Top1-induced lesions and CtIP is known to associate directly with transcription-associated complexes in mammalian cells. Here we investigate the role of Sae2/CtIP at single-strand lesions in budding yeast and in human cells and find that depletion of Sae2/CtIP promotes the accumulation of stalled RNA polymerase and RNA-DNA hybrids at sites of highly expressed genes. Overexpression of the RNA-DNA helicase Senataxin suppresses DNA damage sensitivity and R-loop accumulation in Sae2/CtIP-deficient cells, and a catalytic mutant of CtIP fails to complement this sensitivity, indicating a role for CtIP nuclease activity in the repair process. Based on this evidence, we propose that R-loop processing by 5' flap endonucleases is a necessary step in the stabilization and removal of nascent R-loop initiating structures in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.42733"xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Fu Q."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Wen X."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Paull T.T."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Kao C.H."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Arora S."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Leung J.W."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Miller K.M."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/author | "Makharashvili N."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/pages | "e42733"xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/title | "Sae2/CtIP prevents R-loop accumulation in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/30523780 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30523780 |
| http://purl.uniprot.org/citations/30523780 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30523780 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z520-mappedCitation-30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30523780 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z550-mappedCitation-30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30523780 |
| http://purl.uniprot.org/uniprot/#_A0A8H4C2I8-mappedCitation-30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30523780 |
| http://purl.uniprot.org/uniprot/#_B4DYE6-mappedCitation-30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30523780 |
| http://purl.uniprot.org/uniprot/#_P46946-mappedCitation-30523780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30523780 |