| http://purl.uniprot.org/citations/30524949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30524949 | http://www.w3.org/2000/01/rdf-schema#comment | "Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin-dependent manner. Here, we used reverse-phase protein array (RPPA) to analyze NPNT-triggered intracellular signaling in the 66cl4 mouse breast cancer cell line. The results showed that the integrin-binding enhancer motif is important for the cellular effects upon NPNT interaction with its receptors, including phosphorylation of p38 mitogen-activated protein kinase (MAPK). Furthermore, analysis using prediction tools suggests involvement of NPNT in promoting cell viability. In conclusion, our results indicate that NPNT, via its integrin-binding motifs, promotes cell viability through phosphorylation of p38 MAPK."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.org/dc/terms/identifier | "doi:10.1002/2211-5463.12544"xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/author | "Svineng G."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/author | "Steigedal T.S."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/author | "Chawla K."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/author | "Magnussen S.N."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/author | "Toraskar J."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/name | "FEBS Open Bio"xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/pages | "1992-2001"xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/title | "Nephronectin mediates p38 MAPK-induced cell viability via its integrin-binding enhancer motif."xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30524949 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30524949 |
| http://purl.uniprot.org/citations/30524949 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30524949 |
| http://purl.uniprot.org/uniprot/#_P47811-mappedCitation-30524949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30524949 |
| http://purl.uniprot.org/uniprot/P47811 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30524949 |