| http://purl.uniprot.org/citations/30528239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30528239 | http://www.w3.org/2000/01/rdf-schema#comment | "The dysregulation of the tight junctions (TJs) protein claudin-7 is closely related to the development and metastasis of colorectal cancer (CRC). The aim of this study was to investigate the expression of claudin-7 and characterize the relationship between claudin-7 expression and epithelial-mesenchymal transition (EMT) in CRC. In this study, the expression of claudin-7, E-cadherin, vimentin and snail-1 was detected by immunohistochemistry (IHC) in a set of 80 CRC specimens comprising 20 specimens each of well-differentiated, moderately differentiated, poorly differentiated and liver metastases tissues. The correlation between claudin-7 and EMT-related proteins in the stably transfected claudin-7 knockdown HCT116 cell line was analyzed by IHC, immunofluorescence (IF), Western blotting (WB) and nude mouse xenograft models. The results revealed that the expression of claudin-7 was downregulated as CRC tissue differentiation grade decreased, and that low claudin-7 expression corresponded to the downregulation of E-cadherin (r = 0.725, p < 0.001) and upregulation of vimentin (r = -0.376, p = 0.001) and snail-1 (r = -0.599, p < 0.001). Additionally, in the claudin-7 knockdown HCT116 cell line, the staining intensity and expression of E-cadherin was decreased, while the immunoreactivity and expression of vimentin and snail-1 was increased. Futhermore, the result of tumor formation experiment was consistent with CRC tissues. In conclusion, the expression of claudin-7 in CRC is downregulated as differentiation grade decreases. Claudin-7 downregulation may promote the invasion and metastasis of CRC by regulating EMT. Our results provide new perspectives for a potential therapeutic target for CRC."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.10.049"xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/pages | "797-804"xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/title | "Claudin-7 downregulation induces metastasis and invasion in colorectal cancer via the promotion of epithelial-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://purl.uniprot.org/core/volume | "508"xsd:string |
| http://purl.uniprot.org/citations/30528239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30528239 |
| http://purl.uniprot.org/citations/30528239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30528239 |
| http://purl.uniprot.org/uniprot/#_A0A384ME58-mappedCitation-30528239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528239 |
| http://purl.uniprot.org/uniprot/#_F5H496-mappedCitation-30528239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528239 |
| http://purl.uniprot.org/uniprot/#_O95471-mappedCitation-30528239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528239 |
| http://purl.uniprot.org/uniprot/O95471 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30528239 |
| http://purl.uniprot.org/uniprot/A0A384ME58 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30528239 |
| http://purl.uniprot.org/uniprot/F5H496 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30528239 |