| http://purl.uniprot.org/citations/30528855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30528855 | http://www.w3.org/2000/01/rdf-schema#comment | "Reactive oxygen species (ROS) modulate the growth of neural stem/precursor cells (NS/PCs) and participate in hippocampus-associated learning and memory. However, the origin of these regulatory ROS in NS/PCs is not fully understood. In the present study, we found that Nox4, a ROS-producing NADPH oxidase family protein, is expressed in primary cultured NS/PCs and in those of the adult mouse brain. Nox inhibitors VAS 2870 and GKT137831 or Nox4 deletion attenuated bFGF-induced proliferation of cultured NS/PCs, while lentivirus-mediated Nox4 overexpression increased the production of H2O2, the phosphorylation of Akt, and the proliferation of cultured NS/PCs. Nox4 did not significantly affect the potential of cultured NS/PCs to differentiate into neurons or astrocytes. The histological and functional development of the hippocampus appeared normal in Nox4-/- mice. Although pathological and functional damages in the hippocampus induced by the neurotoxin trimethyltin were not significantly different between wild-type and Nox4-/- mice, the post-injury reactive proliferation of NS/PCs and neurogenesis in the subgranular zone (SGZ) of the dentate gyrus were significantly impaired in Nox4-/- animals. Restoration from the trimethyltin-induced impairment in recognition and spatial working memory was also significantly attenuated in Nox4-/- mice. Collectively, our findings suggest that Nox4 participates in NS/PC proliferation and neurogenesis in the hippocampus following injury, thereby helping to restore memory function."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2018.11.046"xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Nakashima K."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Shibahara T."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Yoshikawa Y."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Tachibana M."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Nakashima H."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Kuroda J."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Kitazono T."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Komori M."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Wakisaka Y."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/author | "Ago T."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/pages | "193-205"xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/title | "Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury."xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://purl.uniprot.org/core/volume | "398"xsd:string |
| http://purl.uniprot.org/citations/30528855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30528855 |
| http://purl.uniprot.org/citations/30528855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30528855 |
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| http://purl.uniprot.org/uniprot/#_B5AN18-mappedCitation-30528855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528855 |
| http://purl.uniprot.org/uniprot/#_B2RSM1-mappedCitation-30528855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528855 |
| http://purl.uniprot.org/uniprot/#_Q9JHI8-mappedCitation-30528855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528855 |
| http://purl.uniprot.org/uniprot/#_S4R1R3-mappedCitation-30528855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30528855 |