| http://purl.uniprot.org/citations/30532989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30532989 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock protein 72 (HSP72) is a major inducible molecule in the heat shock response that enhances intracellular stress tolerance. Decreased expression of HSP72 is observed in type 2 diabetes, which may contribute to the development of insulin resistance and chronic inflammation. We used HSP72 knockout (HSP72-KO) mice to investigate the impact of HSP72 on glucose metabolism and endoplasmic reticulum (ER) stress, particularly in the liver. Under a high-fat diet (HFD) condition, HSP72-KO mice showed glucose intolerance, insulin resistance, impaired insulin secretion, and enhanced hepatic gluconeogenic activity. Furthermore, activity of the c-Jun NH2-terminal kinase (JNK) was increased and insulin signaling suppressed in the liver. Liver-specific expression of HSP72 by lentivirus (lenti) in HFD-fed HSP72-KO mice ameliorated insulin resistance and hepatic gluconeogenic activity. Furthermore, increased adipocyte size and hepatic steatosis induced by the HFD were suppressed in HSP72-KO lenti-HSP72 mice. Increased JNK activity and ER stress upon HFD were suppressed in the liver as well as the white adipose tissue of HSP72-KO lenti-HSP72 mice. Thus, HSP72 KO caused a deterioration in glucose metabolism, hepatic gluconeogenic activity, and β-cell function. Moreover, liver-specific recovery of HSP72 restored glucose homeostasis. Therefore, hepatic HSP72 may play a critical role in the pathogenesis of type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00215.2018"xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Takaki Y."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Sakaguchi M."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Ono K."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Motoshima H."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Matsumura T."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Kai H."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Araki E."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Kitano S."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Matsuyama R."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Goto R."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Kawashima J."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Igata M."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/author | "Hanatani S."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/pages | "E305-E318"xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/title | "Impact of hepatic HSP72 on insulin signaling."xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/30532989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30532989 |
| http://purl.uniprot.org/citations/30532989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30532989 |
| http://purl.uniprot.org/uniprot/#_A1E2B8-mappedCitation-30532989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30532989 |