| http://purl.uniprot.org/citations/30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30538245 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory mechanisms controlling the pool size of spleen dendritic cells (DC) remain incompletely understood. DCs are continuously replenished from hematopoietic stem cells, and FLT3-mediated signals cell-intrinsically regulate homeostatic expansion of spleen DCs. Here we show that combining FLT3 and CSF1R-deficiencies results in specific and complete abrogation of spleen DCs in vivo. Spatiotemporally controlled CSF1R depletion reveals a cell-extrinsic and non-hematopoietic mechanism for DC pool size regulation. Lack of CSF1R-mediated signals impedes the differentiation of spleen macrophages of embryonic origin, and the resulted macrophage depletion during development or in adult mice results in loss of DCs. Moreover, embryo-derived macrophages are important for the physiologic regeneration of DC after activation-induced depletion in situ. In summary, we show that the differentiation of DC and their regeneration relies on ontogenetically distinct spleen macrophages, thereby providing a novel regulatory principle that may also be important for the differentiation of other hematopoietic cell types."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-07685-x"xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Kranz A."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Pollard J.W."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Waskow C."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Naumann R."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Eitler J."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/author | "Percin G.I."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/pages | "5279"xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/title | "CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages."xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30538245 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30538245 |
| http://purl.uniprot.org/citations/30538245 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30538245 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
| http://purl.uniprot.org/uniprot/#_A1E2H6-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
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| http://purl.uniprot.org/uniprot/#_A0A494BBK8-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
| http://purl.uniprot.org/uniprot/#_O35305-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
| http://purl.uniprot.org/uniprot/#_D3YTW1-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |
| http://purl.uniprot.org/uniprot/#_D3Z090-mappedCitation-30538245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30538245 |