| http://purl.uniprot.org/citations/30546012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30546012 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt/Wg-signalling is critical signalling in all metazoans. Recent studies suggest that IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independently of their ciliary role. Whether they function together in Wnt-signalling and their mechanistic role in the pathway remained unresolved. Here we demonstrate that Kinesin-2 and IFT-A proteins act as a complex during Drosophila Wg-signalling, affecting pathway activity in the same manner, interacting genetically and physically, and co-localizing with β-catenin, the mediator of Wnt/Wg-signalling on microtubules. Following pathway activation, Kinesin-2/IFT-A mutant cells exhibit high cytoplasmic β-catenin levels, yet fail to activate Wg-targets. In mutant tissues in both, Drosophila and mouse/MEFs, nuclear localization of β-catenin is markedly reduced. We demonstrate a conserved, motor-domain dependent function of the Kinesin-2/IFT-A complex in promoting nuclear translocation of β-catenin. We show that this is mediated by protecting β-catenin from a conserved cytoplasmic retention process, thus identifying a mechanism for Kinesin-2/IFT-A in Wnt-signalling that is independent of their ciliary role."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-07605-z"xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Esposito D."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Aaronson S.A."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Iomini C."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Balmer S."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/author | "Vuong L.T."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/pages | "5304"xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/title | "Kinesin-2 and IFT-A act as a complex promoting nuclear localization of beta-catenin during Wnt signalling."xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30546012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30546012 |
| http://purl.uniprot.org/citations/30546012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30546012 |
| http://purl.uniprot.org/uniprot/P18824#attribution-ADC842FF4431B867556F6EC45F70A990 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/P09615#attribution-ADC842FF4431B867556F6EC45F70A990 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/Q9VZ07#attribution-35F02DCB7D7966D6FB787DD1672ACB01 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/Q7KTZ4#attribution-35F02DCB7D7966D6FB787DD1672ACB01 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/Q9VRK9#attribution-C1BD3F9B4AC8446668A035BCB56F9189 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHW0-mappedCitation-30546012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/#_A4V3M5-mappedCitation-30546012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/#_B7Z0S0-mappedCitation-30546012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30546012 |
| http://purl.uniprot.org/uniprot/#_B7Z139-mappedCitation-30546012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30546012 |