| http://purl.uniprot.org/citations/30556901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30556901 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously demonstrated co-receptor level-associated functional heterogeneity in apparently homogeneous naive peripheral CD4 T cells, dependent on MHC-mediated tonic signals. Maturation pathways can differ between naive CD4 and naive CD8 cells, so we tested whether the latter showed similar co-receptor level-associated functional heterogeneity. We report that, when either polyclonal and T-cell receptor (TCR)-transgenic monoclonal peripheral naive CD8 T cells from young mice were separated into CD8hi and CD8lo subsets, CD8lo cells responded poorly, but CD8hi and CD8lo subsets of CD8 single-positive (SP) thymocytes responded similarly. CD8lo naive CD8 T cells were smaller and showed lower levels of some cell-surface molecules, but higher levels of the negative regulator CD5. In addition to the expected peripheral decline in CD8 levels on transferred naive CD8 T cells in wild-type (WT) but not in MHC class I-deficient recipient mice, short-duration naive T-cell-dendritic cell (DC) co-cultures in vitro also caused co-receptor down-modulation in CD8 T cells but not in CD4 T cells. Constitutive pZAP70/pSyk and pERK levels ex vivo were lower in CD8lo naive CD8 T cells and dual-specific phosphatase inhibition partially rescued their hypo-responsiveness. Bulk mRNA sequencing showed major differences in the transcriptional landscapes of CD8hi and CD8lo naive CD8 T cells. CD8hi naive CD8 T cells showed enrichment of genes involved in positive regulation of cell cycle and survival. Our data show that naive CD8 T cells show major differences in their signaling, transcriptional and functional landscapes associated with subtly altered CD8 levels, consistent with the possibility of peripheral cellular aging."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.13036"xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Rane S."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Galande S."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "George A."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Rath S."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Khare S.P."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Pradhan S.J."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Bal V."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Durdik J.M."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Gund R."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Balyan R."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/author | "Chawla A.S."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/pages | "384-401"xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/title | "Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells."xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/30556901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30556901 |
| http://purl.uniprot.org/citations/30556901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30556901 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-30556901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30556901 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-30556901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30556901 |
| http://purl.uniprot.org/uniprot/#_Q3U543-mappedCitation-30556901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30556901 |
| http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-30556901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30556901 |