| http://purl.uniprot.org/citations/30558886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30558886 | http://www.w3.org/2000/01/rdf-schema#comment | "Based on our recent finding that FBP21 regulates human Brr2 helicase activity involved in the activation of the spliceosomal B-complex, we investigated the structural and dynamic contribution of FBP21 to the interaction. By using NMR spectroscopy, we could show that the 50 C-terminal residues of FBP21 (FBP21326-376), which are sufficient to fully form the interaction with the C-terminal Sec63 unit of Brr2 (Brr2C-Sec63), adopt a random-coil conformation in their unbound state. Upon interaction with Brr2C-Sec63, 42 residues of FBP21326-376 cover the large binding site on Brr2C-Sec63 in an extended conformation. Short charged motifs are steering complex formation, still allowing the bound state to retain dynamics. Based on fragment docking in combination with experimental restraints, we present models of the complex structure. The FBP21326-376/Brr2C-Sec63 interaction thus presents an example of an intrinsically disordered protein/ordered-protein interaction in which a large binding site provides high specificity and, in combination with conformational disorder, displays a relatively high affinity."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bpj.2018.11.3123"xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Freund C."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Sticht J."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Abualrous E.T."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Henning L.M."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Bertazzon M."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/author | "Licha J.R."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/pages | "406-418"xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/title | "FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase."xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/30558886 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30558886 |
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