| http://purl.uniprot.org/citations/30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30562514 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 have also been suggested, it has remained unclear whether Ub-dependent and -independent functions of PRC1 operate differentially in a developmental context. Here, we show that the E3 ubiquitin ligase activity of Ring1B, a core component of PRC1, is necessary for the temporary repression of key neuronal genes in neurogenic (early-stage) neural stem or progenitor cells (NPCs) but is dispensable for the persistent repression of these genes associated with the loss of neurogenic potential in astrogliogenic (late-stage) NPCs. Our results also suggest that histone deacetylase (HDAC) activity of the NuRD/MBD3 complex and Phc2-dependent PRC1 clustering are necessary for the transition from the Ub-dependent to -independent function of PRC1. Together, these results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2018.11.018"xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Gotoh Y."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Kishi Y."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Hirabayashi Y."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Tsuboi M."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/author | "Yokozeki W."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/pages | "758-772.e5"xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/title | "Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex."xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/30562514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30562514 |
| http://purl.uniprot.org/citations/30562514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30562514 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ3-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_A0A087WP87-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_A0A068BFS4-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_A0A087WRE9-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_G3UWQ7-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_G3UXT4-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_G3UY19-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_G3UZL8-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |
| http://purl.uniprot.org/uniprot/#_D3YTR4-mappedCitation-30562514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30562514 |