| http://purl.uniprot.org/citations/30565858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30565858 | http://www.w3.org/2000/01/rdf-schema#comment | "This study was designed to detecting the influences of lncRNA MEG3 in prostate cancer. Aberrant lncRNAs expression profiles of prostate cancer were screened by microarray analysis. The qRT-PCR and Western blot were employed to investigating the expression levels of lncRNA MEG3, miR-9-5p and QKI-5. The luciferase reporter assay was utilized to testifying the interactions relationship among these molecules. Applying CCK-8 assay, wound healing assay, transwell assay and flow cytometry in turn, the cell proliferation, migration and invasion abilities as well as apoptosis were measured respectively. LncRNA MEG3 was a down-regulated lncRNA in prostate cancer tissues and cells and could inhibit the expression of miR-9-5p, whereas miR-9-5p down-regulated QKI-5 expression. Overexpressed MEG3 and QKI-5 could decrease the abilities of proliferation, migration and invasion in prostate cancer cells effectively and increased the apoptosis rate. On the contrary, miR-9-5p mimics presented an opposite tendency in prostate cancer cells. Furthermore, MEG3 inhibited tumour growth and up-regulated expression of QKI-5 in vivo. LncRNA MEG3 was a down-regulated lncRNA in prostate cancer and impacted the abilities of cell proliferation, migration and invasion, and cell apoptosis rate, this regulation relied on regulating miR-9-5p and its targeting gene QKI-5."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.13658"xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Ye Z."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/author | "Xi X."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/pages | "29-38"xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/title | "LncRNA MEG3 inhibits the progression of prostate cancer by modulating miR-9-5p/QKI-5 axis."xsd:string |
| http://purl.uniprot.org/citations/30565858 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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