| http://purl.uniprot.org/citations/30566873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30566873 | http://www.w3.org/2000/01/rdf-schema#comment | "The exact identity of castrate-resistant (CR) cells and their relation to CR prostate cancer (CRPC) is unresolved. We use single-cell gene profiling to analyze the molecular heterogeneity in basal and luminal compartments. Within the luminal compartment, we identify a subset of cells intrinsically resistant to castration with a bi-lineage gene expression pattern. We discover LY6D as a marker of CR prostate progenitors with multipotent differentiation and enriched organoid-forming capacity. Lineage tracing further reveals that LY6D+ CR luminal cells can produce LY6D- luminal cells. In contrast, in luminal cells lacking PTEN, LY6D+ cells predominantly give rise to LY6D+ tumor cells, contributing to high-grade PIN lesions. Gene expression analyses in patients' biopsies indicate that LY6D expression correlates with early disease progression, including progression to CRPC. Our studies thus identify a subpopulation of luminal progenitors characterized by LY6D expression and intrinsic castration resistance. LY6D may serve as a prognostic maker for advanced prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.11.069"xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Brown M."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Guo G."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Linn D.E."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Steiner I."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Yuan G.C."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Peset I."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Pakula H."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Ashton G."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Baena E."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Barros-Silva J.D."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/author | "Clarke N.W."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/pages | "3504-3518.e6"xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/title | "Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer."xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/30566873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30566873 |
| http://purl.uniprot.org/citations/30566873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30566873 |