| http://purl.uniprot.org/citations/30567484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30567484 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective-TCF7L2 (transcription factor 7-like 2) is a Wnt-regulated transcription factor that maintains stemness and promotes proliferation in embryonic tissues and adult stem cells. Mice with a coronary artery disease-linked mutation in Wnt-coreceptor LRP6 (LDL receptor-related protein 6) exhibit vascular smooth muscle cell dedifferentiation and obstructive coronary artery disease, which are paradoxically associated with reduced TCF7L2 expression. We conducted a comprehensive study to explore the role of TCF7L2 in vascular smooth muscle cell differentiation and protection against intimal hyperplasia. Approach and Results-Using multiple mouse models, we demonstrate here that TCF7L2 promotes differentiation and inhibits proliferation of vascular smooth muscle cells. TCF7L2 accomplishes these effects by stabilization of GATA6 (GATA-binding protein 6) and upregulation of SM-MHC (smooth muscle cell myosin heavy chain) and cell cycle inhibitors. Accordingly, TCF7L2 haploinsufficient mice exhibited increased susceptibility to injury-induced hyperplasia, while mice overexpressing TCF7L2 were protected against injury-induced intimal hyperplasia compared with wild-type littermates. Consequently, the overexpression of TCF7L2 in LRP6 mutant mice rescued the injury-induced intimal hyperplasia. Conclusions-Our novel findings imply cell type-specific functional role of TCF7L2 and provide critical insight into mechanisms underlying the pathogenesis of intimal hyperplasia."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.118.311830"xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Hong L."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Xie Y."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Adeniran A."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Esteghamat F."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Mani A."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Srivastava R."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Ge G."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Nobrega M."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Martin K.A."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Bhat N."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Geirsson A."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/author | "Rolyan H."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/pages | "250-262"xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/title | "TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia."xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/30567484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30567484 |
| http://purl.uniprot.org/citations/30567484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30567484 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A9-mappedCitation-30567484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30567484 |