| http://purl.uniprot.org/citations/30568657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30568657 | http://www.w3.org/2000/01/rdf-schema#comment | "The integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. This integrin can be present either in a closed or in an open active conformation and its activation upon T-cell receptor (TCR) stimulation is a critical step to allow interaction with APCs. In this study we demonstrate that the serine/threonine kinase Ndr2 is critically involved in the initiation of TCR-mediated LFA-1 activation (open conformation) in T cells. Ndr2 itself becomes activated upon TCR stimulation and phosphorylates the intracellular integrin binding partner Filamin A (FLNa) at serine 2152. This phosphorylation promotes the dissociation of FLNa from LFA-1, allowing for a subsequent association of Talin and Kindlin-3 which both stabilize the open conformation of LFA-1. Our data suggest that Ndr2 activation is a crucial step to initiate TCR-mediated LFA-1 activation in T cells."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.02852"xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Turk B.E."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Stork O."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Freund C."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Devroe E."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Muller A.J."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Reinhold A."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Seifert A."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Reichardt P."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Mix C."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Waldt N."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/author | "Demiray Y.E."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/pages | "2852"xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/title | "Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells."xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30568657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30568657 |
| http://purl.uniprot.org/citations/30568657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30568657 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVR1-mappedCitation-30568657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30568657 |
| http://purl.uniprot.org/uniprot/#_A0A075TSG1-mappedCitation-30568657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30568657 |