| http://purl.uniprot.org/citations/30575211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30575211 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that an inflammation-related, molecule leucine-rich alpha-2 glycoprotein (LRG) enhances the transforming growth factor (TGF)-β1-induced phosphorylation of Smad proteins and is elevated in patients with pancreatic ductal adenocarcinoma (PDAC). As TGF-β/Smad signaling is considered to play a key role in epithelial-mesenchymal transition (EMT), we attempted to clarify the mechanism underlying LRG-related EMT in relation to metastasis in PDAC. We cultured LRG-overexpressing PDAC cells (Panc1/LRG) and evaluated the morphology, EMT-related molecules and TGF-β/Smad signaling pathway in these cells. We also assessed the LRG levels in plasma and resected specimens from patients with PDAC. Inflammatory cytokines induced LRG production in PDAC cells. A spindle-like shape was visualized more frequently than other shapes in Panc1/LRG with TGF-β1 exposure. The expression of E-cadherin in Panc1/LRG was decreased with TGF-β1 exposure. Invasion increased with TGF-β1 stimulation of Panc1/LRG. The phosphorylation of smad2 in Panc1/LRG was increased in comparison with parental Panc1 under TGF-β1 stimulation. In the plasma LRG-high group, the recurrence rate tended to be higher and the recurrence-free survival (RFS) tended to be worse in comparison with the plasma LRG-low group. LRG enhanced EMT induced by TGF-β signaling, thus indicating that LRG has a significant effect on the metastasis of PDAC."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.13918"xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Wada H."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Naka T."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Serada S."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Eguchi H."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Gotoh K."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Yamada D."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Doki Y."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Asaoka T."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Iwagami Y."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/author | "Otsuru T."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/pages | "985-996"xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/title | "Epithelial-mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine-rich alpha-2 glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/30575211 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30575211 |
| http://purl.uniprot.org/citations/30575211 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30575211 |