| http://purl.uniprot.org/citations/30578820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30578820 | http://www.w3.org/2000/01/rdf-schema#comment | "UVB-induced skin damage is attributable to reactive oxygen species, which are triggered by intracellular Ca2+ signals. However, exactly how the reactive oxygen species are triggered by intracellular Ca2+ upon UVB irradiation remains obscure. Here, we show that UVB induces Ca2+ signals via sequential generation of the following Ca2+ messengers: inositol 1,4,5-trisphosphate, nicotinic acid adenine dinucleotide phosphate, and cyclic ADP-ribose. UVB induced H2O2 production through NADPH oxidase 4 activation, which is downstream to inositol 1,4,5-trisphosphate and nicotinic acid adenine dinucleotide phosphate. H2O2 derived from NADPH oxidase 4 activated CD38 to produce cyclic ADP-ribose. UVB first evoked the pannexin channel to release ATP, which acts on P2X7 receptor to generate inositol 1,4,5-trisphosphate. Inhibitors of these messengers, as well as antioxidants, blocked UVB-induced Ca2+ signals and IL-1β secretion in keratinocytes. Furthermore, ablation of CD38 and NADPH oxidase 4 protected against UVB-induced inflammation and IL-1β secretion in the murine epidermis. These results show that UVB induces IL-1β secretion through cross-talk between Ca2+ and reactive oxygen species, providing insight towards potential targets against UVB-induced inflammation."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jid.2018.12.005"xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Kim Y.W."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Park K.H."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Jang K.Y."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Kim U.H."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Nam T.S."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Park D.R."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/author | "Chung H.T."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/pages | "1362-1372"xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/title | "The Essential Role of Capisup>2+pi/sup> Signals in UVB-Induced IL-1beta Secretion in Keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/30578820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30578820 |
| http://purl.uniprot.org/citations/30578820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30578820 |
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| http://purl.uniprot.org/uniprot/#_B5AN18-mappedCitation-30578820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30578820 |
| http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-30578820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30578820 |
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| http://purl.uniprot.org/uniprot/#_E9Q802-mappedCitation-30578820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30578820 |