| http://purl.uniprot.org/citations/30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30588710 | http://www.w3.org/2000/01/rdf-schema#comment | "JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the mechanism of its post-transcriptional regulation in cancer cells remains elusive. We performed a computational analysis of transcriptomic data from a set of 103 breast cancer patients, which, along with JARID1B upregulation, showed a strong downregulation of 2 microRNAs (miRNAs), mir-381 and mir-486, potentially targeting its mRNA. We showed that both miRNAs can target JARID1B 3'UTR and reduce luciferase's activity in a complementarity-driven repression assay. Moreover, MCF7 breast cancer cells overexpressing JARID1B showed a strong protein reduction when transfected with mir-486. This protein's decrease is accompanied by accumulation of DNA damage, enhanced radiosensitivity and increase of BRCA1 mRNA, 3 features previously correlated with JARID1B silencing. These results enlighten an important role of a miRNA's circuit in regulating JARID1B's activity and suggest new perspectives for epigenetic therapies."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.13925"xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Negri R."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Presutti C."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Mannironi C."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Licursi V."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Paci P."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Trisciuoglio D."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Mocavini I."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/author | "Pippa S."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/pages | "1232-1243"xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/title | "JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/30588710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30588710 |
| http://purl.uniprot.org/citations/30588710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30588710 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ITA8-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_B3KMS2-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_B3KMS8-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_B3KM92-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_B3KV94-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_O94800-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |
| http://purl.uniprot.org/uniprot/#_Q6UGB8-mappedCitation-30588710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30588710 |