| http://purl.uniprot.org/citations/30589221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30589221 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the mechanism of DNA methylation-mediated gene silencing is extensively studied, relatively little is known about how promoter methylated genes are protected from transcriptional silencing. SUVH1, an Arabidopsis Su(var)3-9 homolog, was previously shown to be required for the expression of a few promoter methylated genes. By chromatin immunoprecipitation combined with sequencing, we demonstrate that SUVH1 binds to methylated genomic loci targeted by RNA-directed DNA methylation. SUVH1 and its homolog SUVH3 function partially redundantly and interact with three DNAJ domain-containing homologs, SDJ1, SDJ2, and SDJ3, thus forming a complex which we named SUVH-SDJ. The SUVH-SDJ complex components are co-localized in a large number of methylated promoters and are required for the expression of a subset of promoter methylated genes. We demonstrate that the SUVH-SDJ complex components have transcriptional activation activity. SUVH1 and SUVH3 function synergistically with SDJ1, SDJ2, and SDJ3 and are required for plant viability. This study reveals how the SUVH-SDJ complex protects promoter methylated genes from transcriptional silencing and suggests that the transcriptional activation of promoter methylated genes mediated by the SUVH-SDJ complex may play a critical role in plant growth and development."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.org/dc/terms/identifier | "doi:10.1111/jipb.12767"xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/author | "He X.J."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/author | "Zhao Q.Q."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/author | "Lin R.N."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/name | "J Integr Plant Biol"xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/pages | "120-139"xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/title | "A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes."xsd:string |
| http://purl.uniprot.org/citations/30589221 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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