| http://purl.uniprot.org/citations/30593928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30593928 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotes have evolved a specific strategy to package DNA. The nucleosome is a 147-base-pair DNA segment wrapped around histone core proteins that plays important roles regulating DNA-dependent biosynthesis and gene expression. Chromatin remodeling complexes (RSC, Remodel the Structure of Chromatin) hydrolyze ATP to perturb DNA-histone contacts, leading to nucleosome sliding and ejection. Here, we utilized tethered particle motion (TPM) experiments to investigate the mechanism of RSC-mediated nucleosome remodeling in detail. We observed ATP-dependent RSC-mediated DNA looping and nucleosome ejection along individual mononucleosomes and dinucleosomes. We found that nucleosome assembly protein 1 (Nap1) enhanced RSC-mediated nucleosome ejection in a two-step disassembly manner from dinucleosomes but not from mononucleosomes. Based on this work, we provide an entire reaction scheme for the RSC-mediated nucleosome remodeling process that includes DNA looping, nucleosome ejection, the influence of adjacent nucleosomes, and the coordinated action between Nap1 and RSC."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2018.11.008"xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Lu Y.H."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Cheng M.Y."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Chow S.Y."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Chen W.L."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Hsu K.W."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Su B.Y."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/author | "Fan H.F."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Gene Regul Mech"xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/pages | "129-140"xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/title | "The synergy between RSC, Nap1 and adjacent nucleosome in nucleosome remodeling."xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://purl.uniprot.org/core/volume | "1862"xsd:string |
| http://purl.uniprot.org/citations/30593928 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30593928 |
| http://purl.uniprot.org/citations/30593928 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30593928 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BY55-mappedCitation-30593928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30593928 |
| http://purl.uniprot.org/uniprot/#_P25293-mappedCitation-30593928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30593928 |
| http://purl.uniprot.org/uniprot/A0A8H4BY55 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30593928 |
| http://purl.uniprot.org/uniprot/P25293 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30593928 |