| http://purl.uniprot.org/citations/30595478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30595478 | http://www.w3.org/2000/01/rdf-schema#comment | "The nature of obesity-associated islet inflammation and its impact on β cell abnormalities remains poorly defined. Here, we explore immune cell components of islet inflammation and define their roles in regulating β cell function and proliferation. Islet inflammation in obese mice is dominated by macrophages. We identify two islet-resident macrophage populations, characterized by their anatomical distributions, distinct phenotypes, and functional properties. Obesity induces the local expansion of resident intra-islet macrophages, independent of recruitment from circulating monocytes. Functionally, intra-islet macrophages impair β cell function in a cell-cell contact-dependent manner. Increased engulfment of β cell insulin secretory granules by intra-islet macrophages in obese mice may contribute to restricting insulin secretion. In contrast, both intra- and peri-islet macrophage populations from obese mice promote β cell proliferation in a PDGFR signaling-dependent manner. Together, these data define distinct roles and mechanisms for islet macrophages in the regulation of islet β cells."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2018.12.003"xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Fu W."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Olefsky J.M."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Ying W."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Wollam J."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Isaac R."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Yang B.H."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Seidman J.S."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Seo J.B."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "Riopel M."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/author | "McNelis J."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/pages | "457-474.e5"xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/title | "Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting beta Cell Proliferation and Function in Obesity."xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/30595478 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30595478 |
| http://purl.uniprot.org/citations/30595478 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30595478 |
| http://purl.uniprot.org/uniprot/#_A0A1C9CJK6-mappedCitation-30595478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595478 |