| http://purl.uniprot.org/citations/30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30595797 | http://www.w3.org/2000/01/rdf-schema#comment | "Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a dismal prognosis, and the patients carrying EGFR-driven tumors with PTEN mutation do not respond to anti-EGFR therapy. The molecular mechanisms for this resistance remain unknown. Here, we show that PTEN induces the expression of NQO1, a flavoenzyme with dual roles in pro- and antitumorigenesis that decreases the formation of reactive oxygen species (ROS), which mediates the oxidative stress and GBM cell proliferation. NQO1 is reduced in EGFRvIII-overexpressed U87MG cells associated with low ROS, whereas NQO1 is highly escalated in PTEN stably expressed U87MG/EGFRvIII cells with high ROS. Interestingly, knockdown of NQO1 augments ROS and diminishes cell proliferation. Conversely, overexpression of NQO1 attenuates ROS and increases cell proliferation. By contrast, overexpression of PINK1, a PTEN-induced kinase 1, represses ROS and inhibits GBM cell proliferation. Therefore, our findings support that NQO1 displays a paradoxical role in mediating GBM growth in response to tumor suppressor PTEN."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.org/dc/terms/identifier | "doi:10.1155/2018/9146528"xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/author | "Xiang D."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/author | "Lei K."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/name | "Oxid Med Cell Longev"xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/pages | "9146528"xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/title | "NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress."xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://purl.uniprot.org/core/volume | "2018"xsd:string |
| http://purl.uniprot.org/citations/30595797 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30595797 |
| http://purl.uniprot.org/citations/30595797 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR6-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A142FGX1-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPK6-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A2P0XNP6-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A1V0DNR7-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A6G6A825-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_F6KCZ4-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_F6KD01-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_A0A2R4SE35-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_B4DQP5-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |
| http://purl.uniprot.org/uniprot/#_B4DLR8-mappedCitation-30595797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30595797 |